COVID Booster Shots Reshape Immune Memory

Ella Castle

Credit: matejmo/Getty Images T cell populations can change significantly after each COVID mRNA vaccine or booster, a new study from Japan demonstrates. The study, which included about 40 patients and used TCR sequencing, shows certain spike epitopes can become immunodominant. In addition, the team found intra-epitope shifts of vaccine-responding immune […]

COVID explained by healthcare professionals

Ella Castle

AUGUSTA COUNTY – Since the start of the pandemic, over one million Americans have died due to COVID-19. The Center for Disease Control (CDC) public health emergency ended last May, but COVID has not left. The University of Virginia held a press briefing in January with Dr. Costi Sifri, who outlined […]

Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial

Ella Castle

In this long-term longitudinal follow-up of the active treatment group in our original randomized controlled trial, we found HBOT effects on quality of life, emotional well-being, sleep quality and neuropsychological symptoms in long COVID patients were maintained even more than 1 year (486 ± 73) after the last HBOT session. In all […]

Data from China suggest no survival benefit of two antiviral drugs in elderly COVID patients

Ella Castle

gorodenkoff / iStock An observational study in eClinicalMedicine suggests that the antiviral drugs azvudine and nirmatrelvir/ritonavir (Paxlovid) were similarly ineffective in preventing death in elderly patients hospitalized for COVID-19 in China, although the authors acknowledge that the findings may be subject to confounding factors and bias. Azvudine has conditional approval […]

Long COVID: Another Great Pretender

Ella Castle

George D. Lundberg, MD Has COVID replaced syphilis as the great imitator? At the turn of the 20th century, Sir William Osler was quoted as saying, “He who knows syphilis knows medicine.” If you have any doubts about the “imitator” analogy, simply use any broad search engine or AI portal […]

The Minefields Ahead in Long COVID Treatment Development

Ella Castle

Jeremy Faust is editor-in-chief of , an emergency medicine physician at Brigham and Women’s Hospital in Boston, and a public health researcher. He is author of the Substack column Inside Medicine. Follow Emily Hutto is an Associate Video Producer & Editor for MedPage Today. She is based in Manhattan. In […]

Potent new pill provides COVID relief for the masses

Ella Castle

Boxes of the COVID-19 drug simnotrelvir are displayed at a manufacturing facility in Nanjing, China.Credit: VCG via Getty There’s new hope for the average person seeking relief from COVID-19: a drug called simnotrelvir has been shown to speed recovery from mild to moderate disease by about 1.5 days1. A clinical […]

COVID Vaccine Strongly Effective in Young People

Ella Castle

PHILADELPHIA— Children and adolescents who received one of the main COVID-19 vaccines were significantly protected from the illness and showed no increased signs of cardiac complications compared to young people who were not vaccinated, according to a new real-world study led by researchers from the Perelman School of Medicine at […]

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